Multiscale Cross-Modal Mapping of Molecular, Pathologic, and Radiologic Phenotypes in Lipid-Deficient Clear Cell Renal CellCarcinoma
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📝 Original Info
- Title: Multiscale Cross-Modal Mapping of Molecular, Pathologic, and Radiologic Phenotypes in Lipid-Deficient Clear Cell Renal CellCarcinoma
- ArXiv ID: 2512.14750
- Date: 2025-12-13
- Authors: Ying Cui, Dongzhe Zheng, Ke Yu, Xiyin Zheng, Xiaorui Wang, Xinxiang Li, Yan Gu, Lin Fu, Xinyi Chen, Wenjie Mei, Xin-Gui Peng
📝 Abstract
Author Contributions: XGP and WM conceptualized and designed the study and conducted the investigation. YC, DZ, KY, XW, XL, YG, LF, and XC collected the data. YC and DZ analyzed the data. YC, DZ, and KY wrote the original draft. XGP and WM have accessed and verified the data. XGP and WM provided supervision. All authors reviewed and approved the final version of the manuscript. All authors have full access to all the data in the study and have final responsibility for the decision to submit for publication.📄 Full Content
Clear cell renal cell carcinoma (ccRCC), the most common subtype of renal cancer, exhibits pronounced biological and clinical heterogeneity that contributes to substantial variability in patient outcomes [1]. Although TNM staging and pathological features remain central to current clinical decision-making, these metrics incompletely reflect the metabolic and spatial complexity of ccRCC [1]. As a result, a subset of patients categorized as early or intermediate stage still experience disease recurrence or progression, underscoring persistent limitations in accurately assessing tumor aggressiveness before surgery [2,3].
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Reference
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