암 치료를 위한 새로운 항산화제 클래스

초록

본 리뷰는 산화 스트레스와 암 발생·진행 사이의 연관성을 정리하고, 기존·신규 천연·합성 항산화제들의 분자 메커니즘과 임상시험 결과를 종합한다. 자유 라디칼 생성 경로, DNA·단백질·지질 손상 메커니즘, 그리고 피리미딘·쿠마린·티아졸 유도체 등 최신 항산화제 후보군의 전·후임상 데이터를 비판적으로 평가한다.

상세 분석

이 논문은 산화 스트레스를 “활성산소·질소·황 종(ROS/RNS/RSS)의 생성과 항산화 방어 체계의 불균형”으로 정의하고, 미토콘드리아 전자전달계, NADPH 옥시다아제, XO 등 다양한 세포 내·외원에서 ROS가 어떻게 유발되는지를 상세히 설명한다. 특히 초과산화물(O2·‑)이 SOD에 의해 H2O2로 전환되고, Fenton 반응을 통해······································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································································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