Liposomes versus metallic nanostructures: differences in the process of knowledge translation in cancer
📝 Abstract
This research maps the knowledge translation process for two different types of nanotechnologies applied to cancer: liposomes and metallic nanostructures (MNs). We performed a structural analysis of citation networks and text mining supported in controlled vocabularies. In the case of liposomes, our results identify subnetworks (invisible colleges) associated with different therapeutic strategies: nanopharmacology, hyperthermia, and gene therapy. Only in the pharmacological strategy was an organized knowledge translation process identified, which, however, is monopolized by the liposomal doxorubicins. In the case of MNs, subnetworks are not differentiated by the type of therapeutic strategy, and the content of the documents is still basic research. Research on MNs is highly focused on developing a combination of molecular imaging and photothermal therapy.
💡 Analysis
This research maps the knowledge translation process for two different types of nanotechnologies applied to cancer: liposomes and metallic nanostructures (MNs). We performed a structural analysis of citation networks and text mining supported in controlled vocabularies. In the case of liposomes, our results identify subnetworks (invisible colleges) associated with different therapeutic strategies: nanopharmacology, hyperthermia, and gene therapy. Only in the pharmacological strategy was an organized knowledge translation process identified, which, however, is monopolized by the liposomal doxorubicins. In the case of MNs, subnetworks are not differentiated by the type of therapeutic strategy, and the content of the documents is still basic research. Research on MNs is highly focused on developing a combination of molecular imaging and photothermal therapy.
📄 Content
© 2014 Fajardo-Ortiz et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/ . Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php International Journal of Nanomedicine 2014:9 2627–2634 International Journal of Nanomedicine Dovepress submit your manuscript | www.dovepress.com Dovepress 2627 O r i g i n a l R e s e a r c h open access to scientific and medical research Open Access Full Text Article http://dx.doi.org/10.2147/IJN.S62315 David Fajardo-Ortiz1 Luis Duran1 Laura Moreno1 Héctor Ochoa2 Víctor M Castaño1,3,4 1Faculty of Medicine of the National Autonomous University of Mexico, Mexico City, Mexico; 2El Colegio de la Frontera Sur, San Cristobal de las Casas, Mexico; 3Molecular Material Department, Applied Physics and Advanced Technology Center, National Autonomous University of Mexico, Juriquilla, Mexico; 4Advanced Technology Center, CIATEQ, Queretaro, Mexico Correspondence: Víctor M Castaño Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México, Boulevard Juriquilla 3001, Juriquilla, Queretaro 76230, México Tel +1 442 211 2657 Fax +1 442 192 6129 Email meneses@unam.mx Liposomes versus metallic nanostructures: differences in the process of knowledge translation in cancer Abstract: This research maps the knowledge translation process for two different types of nanotechnologies applied to cancer: liposomes and metallic nanostructures (MNs). We performed a structural analysis of citation networks and text mining supported in controlled vocabularies. In the case of liposomes, our results identify subnetworks (invisible colleges) associated with different therapeutic strategies: nanopharmacology, hyperthermia, and gene therapy. Only in the pharmacological strategy was an organized knowledge translation process identified, which, however, is monopolized by the liposomal doxorubicins. In the case of MNs, subnetworks are not differentiated by the type of therapeutic strategy, and the content of the documents is still basic research. Research on MNs is highly focused on developing a combination of molecular imaging and photothermal therapy. Keywords: nanotechnology, citation network analysis, basic research, clinics, health care Introduction Cancer is a growing global health problem: it is estimated that the incidence of new cases of cancer will double by 2030 compared to 2008.1 Population aging is the main force that drives the increased incidence of cancer.2 It has been suggested that the potential adverse effects associated with demographic and epidemiological changes that will occur in the coming decades could be mitigated by technological development.3 However, the technological innovation process is not guided by the burden of disease except in the case of cancers and cardiovascular diseases, and even when these disease groups are disaggregated, correlation is lost.4 Moreover, nanotechnology has been mentioned as a promising source of alternative treatments and diagnostic methods for cancer.5,6 However, until now, there has been no clear evidence that the evolution of knowledge about cancer nanotechnology will lead to innovations in the fight against cancer. On the other hand, it is not well understood how the disruptive character of cancer nanotechnology7 could affect its translation into clinical applications. A technology is disruptive because it breaks with the “normal” line of techno logical development of a particular class of products.8 Disruptive technologies allow the entry of new competitors in a given market, which implies a potential threat to incumbents.9 The opposition between dominant and disruptive technologies is relative: there is a technology development cycle in which dominant designs were originally disruptive innovations.10 In this study, we propose that nanotechnologies are not a homogeneous group and that they are in different stages of evolution of technologi cal development. Number of times this article has been viewed This article was published in the following Dove Press journal: International Journal of Nanomedicine 26 May 2014 International Journal of Nanomedicine 2014:9 submit your manuscript | www.dovepress.com Dovepress Dovepress 2628 Fajardo-Ortiz et al In this study, we compared the knowledge translation for two different kinds of nanotechnologies – liposomes and metallic nanostructures – which, because of their tem porality, are clearly in two different stages of technologi cal development. The former is still in
This content is AI-processed based on ArXiv data.