q-bio.GN 2013-12-24 0

Accurate and robust genomic prediction of celiac disease using statistical learning

Practical application of genomic-based risk stratification to clinical diagnosis is appealing yet performance varies widely depending on the disease and genomic risk score (GRS) method. Celiac disease (CD), a common immune-mediated illness, is strong…

Authors: Gad Abraham, Jason A. Tye-Din, Oneil G. Bhalala

Accurate and robust genomic prediction of celiac disease using statistical learning
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JHQ@M! -/ P G*! HQ@M@RF! BILEBCBHEF! D CC JT N HBNK ! OJM! HQ@! EBNVDK@! ABG@_TBEBRM BTI!]9%^!R@H\@@N! -/PG0!&@GBA@G!BILJGBNK!GLDMGBHF*!HQ@!9"!L@NDEHF!H@NAG!HJ! LMJATC@!I JA@EG! \Q@M@ ! JN@! M@LM @G@N HDHB U@! -/P! BG! G@E@ CH@A ! JTH! JO! D! KMJTL! JO! QBK QEF! CJMM@E DH@A ! -/PG *! \QBE@ ! HQ@! M@GH! M@IDBN! \BHQ! D! Y@MJ! \ @ BKQH *! BN! CJ N HMDGH! \BHQ! 9+ 4 L@NDEBY@A! JM! TNL@NDE BY@A! IJA@EG! \Q@M@! IDNF ! JM! DEE! JO! HQ@G@!-/ PG ! I DF ! M@C @BU@! D ! NJ N 4 Y@MJ!\@BKQH0!vJM! DN! BN 4 A@LHQ!ABGCTGGBJN!JO!HQ@G@!BGGT@G!DNA!HQ@!@OO@C HG!JO! UDMFBNK!9%!E@U@EG! JN!HQ@!L@MOJMIDNC@!JO !ITE HBUDMBDRE@!IJA @EG*!G@@ ! o 6W p0! 1Q@! 9" 4 L@NDEBY@A! -X) ! IJA@E! BG! BNAT C@A! RF! IBNBIBY BNK ! HQ@! 9" 4 L@NDEBY@A! G_TDM@A 4 QBNK@! EJGG ! JU@M! N ! GDILE@G!DNA! p ! -/PG* ! 𝐿 𝛽 ! , 𝛽 = ! 1 2 𝑁 max ! 0 , 1 − 𝑦 ! ( 𝑥 ! ! 𝛽 + 𝛽 ! ) ! ! ! ! ! + 𝜆 𝛽 ! ! ! ! ! , ! \Q@M@ ! x i ! BG! HQ@! p 4 U@CHJM!JO ! K@NJHFL@G ! OJM ! HQ@ ! i HQ ! GDI L E@ ! BN ! DE E@E @ 4 AJGDK@!CJABNK! | W*! "*!+ } *! y i ! 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