On the stability of a maturity structured model of cellular proliferation

We analyse the asymptotic behaviour of a nonlinear mathematical model of cellular proliferation which describes the production of blood cells in the bone marrow. This model takes the form of a system of two maturity structured partial differential equations, with a retardation of the maturation variable and a time delay depending on this maturity. We show that the stability of this system depends strongly on the behaviour of the immature cells population. We obtain conditions for the global stability and the instability of the trivial solution.

💡 Research Summary

The paper investigates the long‑term dynamics of a nonlinear model describing hematopoiesis—the production of blood cells in the bone marrow. The authors formulate the process as a system of two partial differential equations (PDEs) structured by a maturity variable (m\in