Quantitative Biology / Q-Bio.TO

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On drug transport after intravenous administration

On drug transport after intravenous administration

๋ณธ ๋…ผ๋ฌธ์€ ์•ฝ๋ฌผ ๋‹จ๋ฐฑ์งˆ ๊ฒฐํ•ฉ์˜ ์—ญ๋™์„ฑ๊ณผ ์ด๋ฅผ ๊ธฐ๋ฐ˜์œผ๋กœ ํ•œ ์ˆ˜ํ•™์  ๋ชจ๋ธ๋ง ์ ‘๊ทผ๋ฒ•์— ๋Œ€ํ•ด ์‹ฌ๋„ ์žˆ๊ฒŒ ๋‹ค๋ฃฌ๋‹ค. ์ฃผ์š” ๋‚ด์šฉ์€ ๋‹ค์Œ๊ณผ ๊ฐ™๋‹ค: 1. ์•ฝ๋ฌผ ๋‹จ๋ฐฑ์งˆ ๊ฒฐํ•ฉ์˜ ์ •์˜์™€ ์—ญํ•  : ์•ฝ๋ฌผ ๋‹จ๋ฐฑ์งˆ ๊ฒฐํ•ฉ์€ ๋‹จ๋ฐฑ์งˆ๊ณผ ์•ฝ๋ฌผ ๋ถ„์ž ๊ฐ„์˜ ์ผ์‹œ์ ์ธ ๊ฒฐํ•ฉ์œผ๋กœ, ์ด๋Š” ์งˆ๋Ÿ‰ ์ž‘์šฉ ๋ฒ•์น™์— ๋”ฐ๋ผ ๋ฐ€๋ฆฌ์ดˆ ๋‹จ์œ„๋กœ ์ง„ํ–‰๋œ๋‹ค. ์‹คํ—˜์‹ค ํ™˜๊ฒฝ์—์„œ ๋น„๊ฒฐํ•ฉ๋œ ์•ฝ๋ฌผ ๋ถ„์ž๋Š” ์ž์œ  ์•ฝ๋ฌผ ํ˜ˆ์ค‘ ๋†๋„์™€ ์ด ํ˜ˆ์ค‘ ์•ฝ๋ฌผ ๋†๋„์˜ ๋น„์œจ์„ ํ†ตํ•ด ๊ณ„์‚ฐ๋˜๋ฉฐ, ์ด๋Š” ์ƒˆ๋กœ์šด ์•ฝ๋ฌผ ์„ค๊ณ„ ์‹œ ์ค‘์š”ํ•œ ์—ญํ• ์„ ํ•œ๋‹ค. 2. ์ž์œ  ์•ฝ๋ฌผ ๊ฐ€์„ค์— ๋Œ€ํ•œ ์˜๋ฌธ ์ œ๊ธฐ : ์Šค๋ฏธ์Šค ์—ฐ๊ตฌํŒ€์€ '์ž์œ  ์•ฝ๋ฌผ ๊ฐ€์„ค'์— ๋Œ€ํ•ด ์˜๋ฌธ์„

Quantitative Biology
Dinamics of HPV Infection among Women with Cervical Lesions

Dinamics of HPV Infection among Women with Cervical Lesions

: ๋ณธ ์—ฐ๊ตฌ๋Š” ์ธ๋ฅ˜ ์œ ๋‘์ข… ๋ฐ”์ด๋Ÿฌ์Šค(HPV)์˜ ์—ญํ•™์„ ๋ถ„์„ํ•˜๊ณ , ํŠนํžˆ ์ž๊ถ๊ฒฝ๋ถ€ ๋ณ‘๋ณ€์„ ๊ฐ€์ง„ ์—ฌ์„ฑ์—์„œ์˜ HPV ๊ฐ์—ผ๊ณผ ๊ด€๋ จ๋œ ๋‹ค์–‘ํ•œ ์ธก๋ฉด์„ ์กฐ์‚ฌํ•˜์˜€๋‹ค. ์—ฐ๊ตฌ๋Š” 293๋ช…์˜ ์—ฌ์„ฑ ํ™˜์ž๋ฅผ ๋Œ€์ƒ์œผ๋กœ ์ง„ํ–‰๋˜์—ˆ์œผ๋ฉฐ, ์ด๋“ค ์ค‘ ์ž๊ถ๊ฒฝ๋ถ€ ์–‘์„ฑ ๋ณ‘๋ณ€์ด ์žˆ๋Š” ํ™˜์ž๋Š” 88๋ช…(30.0%), CIN(Cervical Intraepithelial Neoplasia)์€ 101๋ช…(34.3%), ๊ทธ๋ฆฌ๊ณ  ์ž๊ถ๊ฒฝ๋ถ€์•”์€ 104๋ช…(35.6%)์œผ๋กœ ๊ตฌ์„ฑ๋˜์—ˆ๋‹ค. HPV ๊ฐ์—ผ์˜ ์ผ๋ฐ˜์ ์ธ ํŠน์ง• ๊ฐ์—ผ๋ฅ  : ์ฒซ ๋ฒˆ์งธ ๊ฒ€์‚ฌ์—์„œ, ์ž๊ถ๊ฒฝ๋ถ€ ์–‘์„ฑ ๋ณ‘๋ณ€์ด ์žˆ๋Š” ํ™˜์ž์˜ 61.3%, CIN ํ™˜

Quantitative Biology
On inconsistencies in passive pharmacokinetics

On inconsistencies in passive pharmacokinetics

๋ณธ ๋…ผ๋ฌธ์€ ์ˆ˜๋™ ์•ฝ๋ฌผ ๋™๋ ฅํ•™์—์„œ ์ผ๊ด€์„ฑ ์—†๋Š” ๊ฒฐ๊ณผ์˜ ์›์ธ์„ ํƒ์ƒ‰ํ•˜๋Š”๋ฐ ์ดˆ์ ์„ ๋งž์ถ”๊ณ  ์žˆ๋‹ค. ์ €์ž๋“ค์€ ์ด๋Ÿฌํ•œ ๋ถˆ์ผ์น˜๊ฐ€ ์ ์ ˆํ•œ ์ง„ํ™” ๋ฐฉ์ •์‹์˜ ๋ถ€์žฌ๋กœ ์ธํ•ด ๋ฐœ์ƒํ•  ๊ฐ€๋Šฅ์„ฑ์ด ๋†’๋‹ค๊ณ  ์ฃผ์žฅํ•œ๋‹ค. ์ด๋Š” ์•ฝ๋ฌผ ๋™๋ ฅํ•™ ์—ฐ๊ตฌ์—์„œ ์ค‘์š”ํ•œ ๋ฌธ์ œ๋ฅผ ์ œ๊ธฐํ•˜๋ฉฐ, ํŠนํžˆ ์‹คํ—˜ ๊ฒฐ๊ณผ์˜ ์ผ๊ด€์„ฑ๊ณผ ์˜ˆ์ธก๋ ฅ์„ ํ–ฅ์ƒ์‹œํ‚ค๋Š” ๋ฐ ์žˆ์–ด ํ•ต์‹ฌ์ ์ธ ์—ญํ• ์„ ํ•œ๋‹ค. ๋…ผ๋ฌธ์€ ํ•œ ๊ฐœ์‹ค ๋ชจ๋ธ์„ ์‚ฌ์šฉํ•˜์—ฌ ์ด๋Ÿฌํ•œ ๋ถˆ์ผ์น˜๋ฅผ ์„ค๋ช…ํ•œ๋‹ค. ์ด ๋ชจ๋ธ์€ ์•ฝ๋ฌผ์ด ์‹œ๊ฐ„์— ๋”ฐ๋ผ ์–ด๋–ป๊ฒŒ ๋ณ€ํ™”ํ•˜๋Š”์ง€ ๋‚˜ํƒ€๋‚ด๋Š” ๋ฐฉ์ •์‹์„ ํ†ตํ•ด ์•ฝ๋ฌผ ๋™๋ ฅํ•™์˜ ๊ธฐ๋ณธ ์›๋ฆฌ๋ฅผ ๋ณด์—ฌ์ค€๋‹ค. ํŠนํžˆ, $C(t)$๋Š” ์‹œ๊ฐ„ $t$์—์„œ์˜ ์•ฝ๋ฌผ ๋†๋„๋ฅผ ๋‚˜

Quantitative Biology
Multiscale approach for bone remodeling simulation based on finite element and neural network computation

Multiscale approach for bone remodeling simulation based on finite element and neural network computation

: ๋ณธ ๋…ผ๋ฌธ์€ ๊ณจ ์žฌ๊ตฌ์„ฑ ๊ณผ์ •์„ ์‹œ๋ฎฌ๋ ˆ์ด์…˜ํ•˜๊ธฐ ์œ„ํ•œ ์ƒˆ๋กœ์šด ๋‹ค์ค‘ ๊ทœ๋ชจ ์ ‘๊ทผ ๋ฐฉ์‹, ์ฆ‰ ํ•˜์ด๋ธŒ๋ฆฌ๋“œ FENN(Finite Element and Neural Network) ๋ฐฉ๋ฒ•์„ ์ œ์•ˆํ•œ๋‹ค. ์ด ๋ฐฉ๋ฒ•์˜ ํ•ต์‹ฌ์€ ์œ ํ•œ ์š”์†Œ ๋ถ„์„๊ณผ ์ธ๊ณต ์‹ ๊ฒฝ๋ง ๊ณ„์‚ฐ์„ ๊ฒฐํ•ฉํ•˜์—ฌ ๊ณจ ์žฌ๊ตฌ์„ฑ ๊ณผ์ •์—์„œ ๋ฐœ์ƒํ•˜๋Š” ๋ณต์žกํ•œ ํ˜„์ƒ์„ ํšจ๊ณผ์ ์œผ๋กœ ๋ชจ๋ธ๋งํ•˜๊ณ  ์‹œ๋ฎฌ๋ ˆ์ด์…˜ํ•  ์ˆ˜ ์žˆ๋„๋ก ํ•˜๋Š” ๊ฒƒ์ด๋‹ค. 1. ๋‹ค์ค‘ ๊ทœ๋ชจ ์ ‘๊ทผ ๋ฐฉ์‹์˜ ํ•„์š”์„ฑ ๊ณจ ์žฌ๊ตฌ์„ฑ์€ ๋ผˆ์˜ ๋ฏธ์„ธ ๊ตฌ์กฐ๋ถ€ํ„ฐ ๊ฑฐ์‹œ์  ํ–‰๋™๊นŒ์ง€ ๋‹ค์–‘ํ•œ ๊ทœ๋ชจ์—์„œ ๋ฐœ์ƒํ•˜๋Š” ๋ณต์žกํ•œ ๊ณผ์ •์ด๋‹ค. ์ด ๊ณผ์ •์„ ์ •ํ™•ํ•˜๊ฒŒ ๋ชจ๋ธ๋งํ•˜๊ธฐ ์œ„ํ•ด์„œ๋Š” ๊ฐ ์ˆ˜์ค€์—์„œ์˜ ์ƒํ˜ธ

Quantitative Biology Model Network Physics

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